You mentioned you've popped fuses in previous speakers, and based on the history you are providing with the EV's, it is pretty clear, to me anyways, that you are overdriving the speakers. Just because they don't have a clip light on them doesn't mean they are indestructible. And if you are using just these and a set of subs for 300-500 people, your are seriously under gunned.
I've always taken the position that more is better. More speakers move more air, while putting less stress on each speaker. Double up the rig. If you can't afford to, your not charging enough.
Also, perhaps it's time to invest in a compressor/limiter?
Out of curiosity, are you monitoring your source and output to ensure you're passing a clean, undistorted signal on to the amplifiers? Are you the type of DJ that runs your board hot (ie, faders at 10)? A bad signal will take out drivers, even if you aren't pushing the rig hard.
Not trying to be hard on you or put you down, just curious. I can tell you from experience that many, many world class DJ's run their boards hot, without knowing better.